The following is a list of available combination buffs and their bonuses. Bring 3 compatible characters or UPCs together, and they'll receive a synergy bonus! The bonus will be present as long as you're using the 3 characters that go together and they are alive. If any member of the synergy team dies during combat the other two characters will lose this buff.
| Name | Team | Buff |
| Soldier's Spirit | Reboldeaux Soldier, Coimbran Trooper, Auch Infantry | ATK Rating +1, DEF Rating +1 |
| Destiny's Chains | Eduardo Gygax, Garcia Gygax, Selva Norte | ATK +5%, ATK Speed +10%, DEF +20% |
| Gunsmiths | Najib Sharif, Grace Bernelli, Lorch Feurholden | ACC +10%, ATK Speed +5%, Penetration +5 |
| Muscle Club | Gracielo, Gertrude Peterson, Soho (normal) | DEF +5, DEF Rating +1, Max HP +1000 |
| Knights of Rescue | Rescue Knight, Romina, Grenmah | Move Speed +10%, Mental RES +10 |
| Junior Club | Ramiro, Tiburon, Claire | DEF Rating +1, Max HP +2000 |
| Marine Heroes | Alejandro, Adelina Esperanza (normal), Soho (normal) | ATK Rating +1, DEF Rating -1, ATK +15%, ATK Speed +5%, DEF -10 |
| Reboldeaux Militia | Andre Janzur, Brunie Etienne, Panfilo de Narvaez (normal) | ATK Rating +2, DEF Rating +2, Max HP +3000, DEF +10 |
| Gigantic Blaster | Scout, Grace Bernelli, Lorch Feurholden | ATK Rating +1, ATK Speed +15%, ACC +30, Critical Rate +16% |
